Effect of dietary black rice outer layer fraction on inducible nitric oxide synthase expression in apoE-deficient mice
- VernacularTitle:膳食黑米皮对载脂蛋白E基因缺陷小鼠诱导型-氧化氮合酶表达的影响
- Author:
Min XIA
;
Huilian ZHU
;
Jing MA
;
Yumei ZHANG
;
Zhihong TANG
;
Wenhua LING
- Publication Type:Journal Article
- Keywords:
Apolipoproteins E;
Nitric oxide-synthase;
Arteriosclerosis;
Gene deletion
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the effect of dietary black rice outlayer fraction (BRF) on inducible nitric oxide synthase (iNOS) expression, and elucidate the possible mechanism of BRF anti-atherogenesis in apoE-deficient mice. METHODS: After 16 weeks intervention by 5% BRF, aortic iNOS activity in different groups was determined by RIA. iNOS mRNA expression in aorta were analyzed by RT-PCR. RESULTS: Mice in BRF group showed weaker expression of iNOS mRNA and lower iNOS activity than those in positive and WRF group (P0.05). CONCLUSION: The supplementation of BRF has dramatically reduced aortic sinus atherosclerotic plaque areas compared to WRF in apoE-deficient mice and its action of anti-atherogenesis may be attributed to its inhibition of iNOS activity and iNOS mRNA expression.
