The expansion of CD4~+ T lymphocytes in rats with colitis induced by 2, 4, 6- trinitrobenzene sulphonic acid
- VernacularTitle:2、4、6-三硝基苯磺酸诱导的大鼠结肠炎CD4~+T细胞增加
- Author:
Li LIU
;
Zhipeng WANG
;
Qibing MEI
;
Chen LI
- Publication Type:Journal Article
- Keywords:
Trinitrobenzensulfonic acid;
Colitis;
ulcerative;
CD4-positive T-lymphocytes;
Rats
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study on the expansion of CD~(4+) T lymphocytes isolated from rats with colitis induced by 2,4,6-trinitrobenzene sulphonic acid (TNBS). METHODS: The numeration and protein expression of CD~(4+) T lymphocytes had been performed by immunohistological analysis, flow cytometry and Western-blot. RESULTS: The numeration of CD4+ T cells and the protein expression of CD~(4+) T lymphocytes increased significantly in rats with colitis induced by 2,4,6-trinitrobenzene sulphonic acid. CONCLUSION: Expansion of CD~(4+) T lymphocytes in TNBS-induced colitis provides us a simple and reducible animal model for research of the new target of therapeutic drug.
