Effects of 9- cis- retinoic acid on transcription of cyclin D1, cdk4 in lung adenocarcinoma cells
- VernacularTitle:9-顺-维甲酸对肺腺癌细胞cyclin D1、cdk4转录的影响
- Author:
Guijie REN
;
Zhifang LIU
;
Lei DING
;
Guoqiang HU
;
Xiaoyan HU
;
Keli TIAN
;
Xueyan YU
- Publication Type:Journal Article
- Keywords:
Tretinoin;
Lung neoplasms;
Cyclin D1;
cdk4
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the mechanism of 9-cis-RA inhibiting the growth of lung adenocarcinoma cells, and we detect the expressional changes of cyclinD1 and cdk4 in lung adenocarcinoma cells PG, A_(549), SPC-A_1 before and after being treated with 9-cis-retinoic acid(9-cis-RA). METHODS: RT-PCR was used to analyse the transcriptional changes of cyclinD1 and cdk4 in PG, A_(549) and SPC-A_1. RESULTS:9-cis-RA decreased the transcription of cyclinD1 in PG and A_(549)(P
