Expression of PAI- 1 in ischemic focus and perifocal areas after 2 hours focal cerebral ischemia with reperfusion in rats
- VernacularTitle:大鼠局灶性脑缺血再灌注病灶及周围区PAI-1表达
- Author:
Ling LI
;
Ruxun HUANG
;
Jun HU
;
Yidong WANG
;
Lin LU
- Publication Type:Journal Article
- Keywords:
Brain ischemia;
Reperfusion;
Plasminogen activator inhibitor 1
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the relation between the changes of the cerebral microvasculature and the expression of plasminogen activator inhibitor-1 (PAI-1) in ischemic focal and perifocal areas after 2 hours focal cerebral ischemia with reperfusion in rats. METHODS: The changes of cerebral microvascular structure were observed by optical microscope and electric microscope, the expression of PAI-1 were assessed by immunohistochemical staining, Western blotting in ischemic focus and perifocal areas after focal cerebral ischemia with reperfusion. RESULTS: The edema of extra-cellular matrix and the hemorrhage of extravessels in ischemic focus and perifocal areas were most severe, and degradation and the defect of basement membrane were also observed after 6 hours and 3 days reperfusion following focal cerebral ischemia. The expression of PAI-1 decreased significantly compared with control group (P
