Study on scavenger receptor A from mouse peritoneal macrophages
- VernacularTitle:小鼠腹腔巨噬细胞A型清道夫受体的研究
- Author:
Jian WEN
;
Wenhua LING
;
Jing MA
;
Zhihong TANG
;
Chaogang CHEN
- Publication Type:Journal Article
- Keywords:
Lipoproteins;
LDL;
Peritoneal cavity;
Macrophages;
Receptors;
lipoprotein
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the role of scavenger receptor A(SR A) in the uptake of oxidized low density lipoprotein(OxLDL) in mouse peritoneal macrophages(MPM). METHODS: Comparing the difference of the uptake of OxLDL in SR A-deficient and wild-type MPM. RESULTS: The results showed that the binding of OxLDL wasn't apparently reduced in SR A-deficient MPM. The association of OxLDL was reduced by 35.8% and degradation of OxLDL was reduced by 42% in SR A-deficient MPM compared with those in wild-type MPM. CONCLUSION: Studies showed that SR A didn't play an important role in the uptake of OxLDL in MPM. Approximately 70% of the uptake of OxLDL in macrophages is attributable to non-SR A receptor.
