The role of telomerase reverse transcriptase in monocrotaline-induced pulmonary hypertension in rats
- VernacularTitle:端粒酶逆转录酶在野百合碱性大鼠肺动脉高压中的作用
- Author:
Jingchun SONG
;
Zhichao LI
- Publication Type:Journal Article
- Keywords:
Telomerase reverse transcriptase;
Hypertension;
pulmonary;
Monocrotaline;
Rats
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM and METHODS: To explore the role of telomerase reverse transcriptase (TERT) in monocrotaline-induced pulmonary hypertension (PH), TERT was investigated by using immunohistochemistry and image analysis on the chronic PH induced by MCT in Sprague-Dawley rats. RESULTS: TERT was positive in pulmonary vascular smooth muscle cells, bronchial smooth muscle cells and chondrocytes in normal group. TERT in MCT group was more positive in pulmonary vascular smooth muscle cells and bronchial smooth muscle cells compared with normal group. CONCLUSION: Over expression of TERT in pulmonary vascular smooth muscle cells and bronchial smooth muscle cells is related to MCT-induced PH.
