Expression of angiopoietin - Ⅱ and its significance in gastric cancer
- VernacularTitle:血管生成素-Ⅱ在胃癌中的表达及其意义
- Author:
Xinge LIU
;
Xiaodong SUN
;
Jinmin WU
- Publication Type:Journal Article
- Keywords:
Angiopoietin-Ⅱ;
Endothelial growth factors;
Reverse transcriptase polymerase chain reaction;
Neoplasm metastasis;
Immunohistochemistry
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the expression of angiopoietin-Ⅱ(Ang-Ⅱ)in primary gastric cancer and the pathological factors that influences it. METHODS: Expression of Ang-Ⅱ and VEGF were studied in 72 primary gastric cancer and adjacent normal tissue by reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemistry. RESULTS: The significant difference of Ang-Ⅱ expression between primary tumor and adjacent normal tissue samples was observed. The correlationship between Ang-Ⅱ and VEGF expression in tumors was statistically significant. The expression of Ang-Ⅱ was related to tumor stage and vascular involvement. CONCLUSION: The results manifested that Ang-Ⅱ may play a role in regulating tumor angiogenesis.
