Effects of ulinastatin on plasma ?-glucuronidase, granulocyte elasta.se and fibronectin during cardiopulmonary bypass
- VernacularTitle:心内直视手术中应用乌司他丁对?-GCD、Gel及Fn的影响
- Author:
Jianbo YU
;
Shanglong YAO
;
Shiying YUAN
- Publication Type:Journal Article
- Keywords:
Cardiopulmonaiy bypass;
Trypsin inhibitor;
Glucuronidase;
Peptide hydrolases;
Neutrophils;
Fibronectins
- From:
Chinese Journal of Anesthesiology
1994;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of ulinastatin on plasma ?-glucuronidase ?-GCD) activity, granulocyte elastase (Gel) and fibronectin (Fn) concentrations and the dose-effect relationships of ulinastatin with them during cardiopulmonary bypass (CPB) .Methods Thirty ASA Ⅱ - Ⅲ patients (19 male, 11 female) aged 3-29 yr, weighing 12-61 kg undergoing elective open heart surgery with CPB were randomly divided into two groups : ulinastatin group (U n - 15) and control group (C n = 12) . In group U patients received ulinastatin 200 000 U in 20 ml of normal saline (NS) infused iv over 10 min after induction of anesthesia and before CPB. An additional 200 000 U of ulinastatin was given iv if CPB lasted for more than 4 h. In control group NS was given iv instead of ulinastatin. Blood samples were taken before anesthesia and after CPB for determination of plasma ?-GCD activity and Gel and Fn levels. The differences in ?-GCD, Gel and Fn between baseline and post-CPB values were calculated (△?-GCD, △Gel, △Fn). In group C the correlation between △?-GCD and AGel;△?-GCD and △Fn; △Gel and △Fn and in group U the correlation of the dose of ulinastatin (U?kg-1 body weight) with △?-GCD /△Gel /△Fn were studied.Results (1) There was no significant difference in plasma ?-GCD activity, Gel and Fn levels between the two groups before anesthesia ( P
