The Inhibition Effect of Fluvastation on IL-18 Expression of Monocyte Cells in Patients with Acute Coronary Syndrome
- VernacularTitle:急性冠脉综合征单核细胞对IL-18的表达及氟伐他汀的抑制作用
- Author:
Yongan YANG
;
Qiming LIU
;
Shenghua ZHOU
- Publication Type:Journal Article
- Keywords:
Acute coronary syndrome;
Fluvastatin;
Monocyte;
Interlukin-18
- From:
Journal of Chinese Physician
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate IL-18 expression of monocyte cells and the inhibition effect of fluvastation on its expression in patients with acute coronary syndrome(ACS). Methods Isolated monocyte cells from peripheral blood of patients with ACS were incubated with different concentrations of fluvastatin, and IL-18 mRNA level of the monocyte cells was detected by reverse transcription polymerase chain reaction(RT-PCR). Results The monocyte cells of peripheral blood in patients with ACS expressed IL-18 mRNA. IL-18 mRNA decreased from 54 1?9 9 to 50 1?12 6(P
