A Clinical Study on the Expression of Cathepsin D and P Selectin in Human Non-small Cell Lung Cancer
- VernacularTitle:非小细胞肺癌组织蛋白酶D和P选择素表达的临床研究
- Author:
Zhongmin WANG
;
Huaihao TANG
;
Hongwei YANG
- Publication Type:Journal Article
- Keywords:
Lung Carcinoma;
Cathepsin D;
P selectin;
Immunohistochemistry;
Prognosis
- From:
Journal of Chinese Physician
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of Cathepsin D and P selectin expression with the clinico-pathologic features and prognosis of non-small cell lung cancer (NSCLC). Methods Immunohistochemistry (S-P method) was applied to detect the expression of Cathepsin D and P selection in 30 NSCLC specimens. Results The positive rates of cathepsin D and P selectin were 66 7% and 76 7% respectively. Cathepsin D expression in NSCLC was positive relation with the tumor size, TNM stage and lymph node metastasis(P0 05). The 3 years survival rate of the patients with the expression of both the Cathepsin D and P selectin was much lower than that of the patients with negative expression of both the Cathepsin D and P selectin(P
