The Expression and Clinical Significance of Vascular Endothelial Growth Factor-C in Non-small Cell Lung Cancer
- VernacularTitle:血管内皮生长因子C在非小细胞肺癌中的表达
- Author:
Weidong ZHANG
;
Qingming XIAO
;
Chengping HU
- Publication Type:Journal Article
- Keywords:
Vascular endothelial growth factor C;
Non-small cell lung cancer;
Metastasis
- From:
Journal of Chinese Physician
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of vascular endothelial growth factor-C(VEGF-C) in human non-small cell lung cancer(NSCLC) and to elucidate its roles in lymph node metastasis and prognosis evaluation. Methods The expression of VEGF-C was examined in 50 NSCLC specimens and 20 archival surgical specimens of human pulmonary inflammatory pseudotumor tissues by immunohistochemistry. Results The positive rate of VEGF-C expression in NSCLC and inflammatory pseudotumor was 44% and 5% respectively. There was significant difference in VEGF-C expression between the two groups. The expression rate of VEGF-C in NSCLC was significantly higher in the patients with lymph node metastasis (66 7%) than that in the patients without lymph node metastasis (23 1%, P
