Effect of Polygonum Multiflorum Thunb on Learning-memory Ability in Rats with Alzheimer Disease and Its Probable Mechanism
- VernacularTitle:何首乌对Alzheimer病模型大鼠学习记忆的影响及其机制的研究
- Author:
Deren HOU
;
Qidong YANG
;
Lin ZHOU
- Publication Type:Journal Article
- Keywords:
Polygonum Multiflorum Thumb;
Alzheimer disease;
Rat;
SOD;
MDA
- From:
Journal of Chinese Physician
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of Polygonum Multiflorum Thunb(PMT) on learning-memory ability in rats with Alzheimer disease(AD) and its probable mechanism. Metheds Rats were trained by Y-maze and were detected its learning-memory ability before the rats received the injection of A?1-40. The rats were treated with different dosage of PMT after the model of AD was set up. The learning-memory ability and the levels of superoxide dismutase (SOD) and malondialdehyde(MDA) were detected. Results Compared with model rats, the rats treated by middle and high-dosage of PMT, the learning-memory ability of was better,the SOD activity of was higher and the MDA concentration of was lower (P
