Effects of Fluvastatin on Expressions of MMP-9 and TIMP-2 after Injury of Blood Balloon
- VernacularTitle:氟伐他汀对血管球囊损伤后MMP-9和TIMP-2表达的影响
- Author:
Xiqin LI
;
Baiyu CHEN
;
Qimin LIU
- Publication Type:Journal Article
- Keywords:
Fluvastatin;
Restenosis;
In site hybridization;
Matrix metalloproteinase-9;
Tissue inhibitors of metalloproteinase-2
- From:
Journal of Chinese Physician
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect and mechanism of fluvastatin preventing and curing restenosis. Methods 48 rabbits were randomly divided into 3 groups. In control group, rabbits were given basic food. In balloon injury group, rabbits were given basic food and balloon injury of general artery on right neck. In fluvastatin balloon group, rabbits were given basic food,ballon injury of general artery and 10mg?kg -1 ?d -1 fluvastatin. The expression of MMP-9 and TIMP-2 of mRNA was detected at 3, 7, 14 and 30 days after injury respectively by method of in site hybridization. Results There was little expression of MMP-9 and TIMP-2 mRNA in control group, and the expression of MMP-9 and TIMP-2 mRNA in middle membrane of blood vessels began at 3 days after blood injury, and reached maximum at 7 days after injury. There was a little expression of MMP-9 and TIMP mRNA in inner membrane of blood vessels at 14 and 30 days after injury, and MMP-9 expression significantly decreased after the fluvastatin interference(P
