The Expression of Interleukin-17,Interferon-?,and Macrophage Inflammatory Protein-3?mRNA in Patients with Psoriasis Vulgaris
- VernacularTitle:寻常性银屑病患者皮损白介素17、干扰素?及巨噬细胞炎性蛋白3?mRNA的表达
- Author:
Jiawen LI
;
Dongsheng LI
;
Houjun LIU
- Publication Type:Journal Article
- Keywords:
Psoriasis;
Interleukin-17;
Interferon typeⅡ;
Macrophage Inflammatory Proteins
- From:
Chinese Journal of Dermatology
1995;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression levels of of interleukin-17(IL-17),interferon-gamma(IFN-?),and macrophage inflammatory protein-3alpha(MIP-3?)mRNA in skin lesions of pa-tients with psoriasis vulgaris.Methods The skin biopsies were collected from skin lesions in31cases of psoriasis vulgaris and16normal controls.The expressions of IL-17,IFN-?,and MIP-3?mRNA were semi-quantitatively analyzed with reverse transcriptase-polymerase chain reaction(RT-PCR)in psoriatic lesions and normal skin tissues.Results Expressions of IL-17,IFN-?,and MIP-3?were presented in all speci-mens of both psoriatic lesions and normal controls.The expression levels were1.142?0.059for IL-17mRNA,1.114?0.056for IFN-?mRNA,1.140?0.052for MIP-3?mRNA,in skin lesions,respectively,which were greatly higher than those in normal controls(0.879?0.034,0.905?0.026and0.868?0.031,respectively)(all P
