Therapeutic Effects of Paclitaxel Solution on Psoriasis-like Pathological Changes of Guinea Pig
- VernacularTitle:紫杉醇溶液外用治疗豚鼠耳部银屑病样病理改变的疗效观察
- Author:
Yina WANG
;
Hong FANG
;
Xingguo ZHANG
;
Lirong CHEN
- Publication Type:Journal Article
- Keywords:
Paclitaxel;
Psoriasis;
Animal testing alternatives
- From:
Chinese Journal of Dermatology
1995;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the therapeutic effects of paclitaxel solution on psoriasis-like pathological changes of guinea pig.Methods5%propranolol ointment was applied on Guinea pigs' ears to produce psoriasis-like pathological changes,then solutions with a paclitaxel concentration of200?g/mL and500?g/mL were applied on the affected ears.The pathological manifestations were investigated under light microscope.Results There were hyperkeratosis,dyskeratosis,acanthosis,psoriasiform elongation of the rete ridges and significant infiltration of mononuclear cells and polymorphic nucleus leucocytes in dermis in the guinea pig models,with the Baker score reaching6.37?0.99averagely.After being treated with paclitaxel solutions of a concentration of200?g/mL and500?g/mL,the pathological manifestations were remarkably improved,with the Baker score reducing to3.13?1.13and2.13?0.81respectively.A significant differ-ence(P
