Down-regulation of Expression of TGF-?Receptors and SMADs mRNA in Psoriatic Lesional Skin
- VernacularTitle:银屑病患者皮损中转化生长因子?受体及SMADs mRNA的低表达
- Author:
Haiyan YU
;
Mrowietz ULRICH
- Publication Type:Journal Article
- Keywords:
Psoriasis;
TGF-?receptor;
Receptors,transforming growth factor beta;
RNA,mes-senger
- From:
Chinese Journal of Dermatology
1995;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To investigate the expression of TGF-?receptors and signaling protein SMADs mRNA in psoriatic lesional and nonlesional skin,and to analyze their role in the pathogenesis of psoriasis.Methods Expression of TGF-?receptorⅠ,TGF-?receptorⅡmRNA and different SMADs(SMAD2,3,4,6,7)mRNA was investigated by real time PCR method in lesional and nonlesional skin of13psoriatic patients and10normal controls.Results The mRNA expression of TGF-?receptors and all kinds of SMADs was significantly down-regulated in psoriatic lesional skin compared with normal skin con-trols(P0.05).Conclusions There is down-regulated TGF-?pathway in psoriatic lesional skin,which may further indicate that lack of TGF-?mediated growth inhibition might play an important role in the pathogenesis of psoriasis.
