Endogenous telomerase catalytic inhibitor PinX1 and its relationship with expression of hTERT and hTRF1 in human colorectal cancer
- VernacularTitle:内源性端粒酶抑制基因在大肠癌中的表达及临床研究
- Author:
Qiang FU
;
Liwei ZHU
;
Pengzhi WANG
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Telomerase;
Inhibitor,gene
- From:
Chinese Journal of General Surgery
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the role of endogenous telomerase catalytic inhibitor PinX1 in the progression of colorectal cancer tissue. Methods The expression of PinX1、telomerase subunits(hTERT) and telomere binding protein(hTRF1) was detected by semi-quantitative RT-PCR. Surgically resected colorectal cancer specimens in 66 cases were studied. Results PinX1 expression is significantly correlated with histologic differentiation,clinical stage and lymph node metastasis of colorectal cancer( Fd =11.40, Fs = 4.22,t =-2.81,P ≤0.05). The level of PinX1 was negatively associated with the expression of hTERT( r =-0.553,P
