Role of vascular endothelial growth factor and its receptor KDR in the progression of colorectal carcinoma
- VernacularTitle:血管内皮生长因子受体KDR在大肠癌发展中的作用
- Author:
Wen LEI
;
Lihua ZHANG
;
Wenzhu ZHANG
;
Xiangru WU
;
Zhongde ZHANG
- Publication Type:Journal Article
- Keywords:
Colonic neoplasms;
Endothelial growth factors;
Neovascularization,pathologic;
Metastasis
- From:
Chinese Journal of General Surgery
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate vascular endothelial growth factor (VEGF),its receptor KDR and angiogenesis in relation to progression of colorectal carcinoma (CC). Methods KDR,VEGF protein expression and microvessel density (MVD) in 102 cases of human CC were examined by immunohistochemical staining. MVD,KDR and VEGF expression were analysed with their relation to histological grade,depth of invasion,Dukes stage,lymph node metastasis,liver metastasis and prognosis of CC. Results MVD was significantly higher in KDR and VEGF-positive CC than in KDR and VEGF-negative CC ( P
