The effect of gastric mucosal blood flow and Na~+-K~+-ATPase activity on gastric transmucosal potential difference during severe intraperitoneal infection in rats
- VernacularTitle:严重腹腔感染时大鼠胃黏膜血流量和Na~+-K~+-ATP酶活性变化对胃黏膜电位差的影响
- Author:
Chao ZHANG
;
Jun JIANG
;
Nianxu SUN
;
Zongcheng YANG
- Publication Type:Journal Article
- Keywords:
Infection;
Na+K+ exchanging ATPase
- From:
Chinese Journal of General Surgery
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of gastric mucosal blood flow and Na + -K + -ATPase activity on gastric transmucosal potential difference during severe intraperitoneal infection in rats. Methods A rat model of intraperitoneal infection was established by cecal ligation and puncture(CLP). Laser Doppler blood flowmeter was used to examine the gastric mucosal blood flow and electric-physiological recorder was applied for measuring gastric mucosal potential difference. Assay of Na + -K + -ATPase activity in gastric mucosal tissue was conducted by biochemistry method. Results Gastric mucosal blood flow(GMBF,mV) in infected group was significantly lower than in control group(43.7?2.8 vs. 57.9?2.7,P
