Significancy of expression of tumor suppressor gene PTEN and p16 protein in cholangiocarcinoma
- VernacularTitle:胆管癌中PTEN和p16抑癌基因蛋白的表达及其临床意义
- Author:
Huaping GU
;
Peizhong SHANG
;
Cuiling ZHOU
- Publication Type:Journal Article
- Keywords:
BILE DUCT NEOPLASMS/pathol;
CHOLANGITIS/pathol;
TUMOR SUPPRESSOR GENE;
GENE p16;
GENES EXPRESSION
- From:
Chinese Journal of General Surgery
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the expression of tumor suppressor gene PTEN and p16 protein and the biologcal behaviors of cholangiocarcinomas.Methods The expression of PTEN and p16 protein in 43 of cholangiocarcinoma tissues and 10 chronic cholangitis tissues were investigated by immunohisto-chemical technique.The relationship between expression of PTEN and p16 protein and the clinicopathological parameters of cholangiocarcinoma was analyzed. Results The positive expression rate of PTEN and p16 protein in cholangiocarcinoma was 39.5% and 44.2%,respectively.The expression of PTEN and p16 protein were positively relatad with the TNM staging,differentiation degree and metastasis of cholangiocarcinoma (P
