Expression of macrophage inflammatory protein-2 in liver injury induced by ischemia and reperfusion in rat
- VernacularTitle:趋化因子MIP-2在大鼠肝缺血/再灌注损伤后的表达
- Author:
Fasheng LIANG
;
Jichang SONG
;
Yingtang GAO
;
Zhiyao ZHANG
;
Wen ZHANG
;
Lichuan LIU
- Publication Type:Journal Article
- Keywords:
LIVER/blood supply;
REPERFUSION INJURY;
CHEMDTACTIC FACTORS,MACROPHAGE
- From:
Chinese Journal of General Surgery
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression and effect of macrophage inflammatory protein-2(MIP-2) in liver injury induced by ischemia/reperfusion(I/R). Methods Thirty-two rats were randomly divided into 4 groups(8 rats in each group):false operation (control) group and 3, 9, 24 hours reperfusion group.The expression of MIP-2 mRNA in hepatic tissue, MIP-2 protein in plasma, the neutrophil infiltration in liver tissue and serum ALT were measured. Results The expression of MIP-2 mRNA in the ischemic tissue was significantly higher than that in nonischemic tissue (P
