Taurine attenuated ?-glycerophosphate-stimulated calcification in cultured rat vascular smooth muscle cells
- VernacularTitle:牛磺酸减轻?-甘油磷酸诱导的大鼠血管平滑肌细胞钙化
- Author:
Baohong ZHANG
;
Zhisheng JIANG
;
Shuheng WANG
;
Dadi NIU
;
Yongzheng PANG
;
Juxiang LI
;
Chaoshu TANG
;
Junba DU
- Publication Type:Journal Article
- Keywords:
Taurine;
Calcification;
Muscle,smooth,vascular
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of taurine on calcification of vascular smooth muscle cells (VSMCs).METHODS: Calcified VSMCs of rat in vitro were induced by ?-glycerophosphate. Cellular calcium content,alkaline phosphatase(ALP) activities and accumulation were measured. DNA synthesis were evaluated by -thymidine (-TdR) incorporation. RESULTS: Calcium content,ALP activities and uptake of calcified VSMCs stimulated by taurine (5-20 mmol/L) were greatly decreased in a concentration-dependent manner as compared with calcified group ( P
