Expression of survivin gene in hematological tumour cell strains
- VernacularTitle:血液肿瘤细胞株细胞survivin基因表达以及ATRA对NB4细胞株survivin基因表达的调节
- Author:
Jun XUE
;
Maofang LIN
;
Zhen CAI
- Publication Type:Journal Article
- Keywords:
Genes,survivin;
Reverse transcriptase polymerase chain reaction;
Cell line;
Tretinoin
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Dami) existed. The transcriptional levels of survivin gene in K562/ADR cell strain was 1.6-fold higher than that in K562 cell strain,but wasn't detected in peripheral blood mononuclear cells(PBMNCs).All-trans retinoic acid significantly decreased survivin mRNA expression levels. CONCLUSION: These data suggest that the survivin gene might be a potential therapeutics target due to the role in anti-apoptosis and drug resistance.
