Expression and significance of c-IAP2 and GAS1 in Hodgkin's lymphoma and anaplastic large cell lymphoma
- VernacularTitle:基因c-IAP2和GAS1在何杰金及间变性大细胞淋巴瘤中表达
- Author:
Hui LI
;
Zihua ZENG
;
Peie ZHENG
;
Guangyu JIANG
;
Hong LI
;
Mingha XIA
- Publication Type:Journal Article
- Keywords:
Lymphoma,Hodgkin;
Lymphoma,large-cell;
Apoptosis;
Genes, c-IAP2;
Genes,GAS1
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To detect the expression of cytoplasmic inhibitor of apoptosis protein 2 (c-IAP2) and growth arrest-specific gene 1 (GAS1) in Hodgkin's lymphoma (HL) and anaplastic large cell lymphoma (ALCL) and to investigate the role of two genes in the pathogenesis of HL and ALCL.METHODS: HE staining,the antibodies CD30,CD15,CD45RO and CD20 were used to screen the cases of HL and ALCL from 288 cases of lymphoma. The clarified HL and ALCL were subjected for immunohistochemical staining by SP and ABC methods to analyze the expression of c-IAP2 and GAS1. RESULTS: ①The positive rate of c-IAP2 in HL was 25/26(96.1%) while that in ALCL was 6/19(31.6%),there presented statistic significance between HL and ALCL groups( P
