Determination of the Plasma Concentration of Ropivacaine in Rabbits by HPLC
- VernacularTitle:高效液相色谱法测定罗哌卡因在家兔体内的血药浓度
- Author:
Hongrong XU
;
Hong WANG
;
Qianzhou LU
;
Weili CHEN
;
Xuening LI
- Publication Type:Journal Article
- Keywords:
ropivacaine;
HPLC;
plasma concentration
- From:
China Pharmacy
1991;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To determinate the plasma concentration of ropivacaine in rabbits by HPLC,and study the secu?rity of ropivacaine in rabbits.METHODS:Nine rabbits were injected with ropivacaine drop by drop with a speed of1mg/(kg?min)until the rabbits died.RESULTS:The mean plasma concentration of ropivacaine in rabbits was224.54?107.45mg/L when the rabbits died.CONCLUSION:Ropivacaine has high security in rabbits.
