Protective Effect of Combination of Xingnaojing and Ligustrazine on Rat's Cortical Neurons of Primary Culture
- VernacularTitle:醒脑静与川芎嗪联用对原代培养的大鼠皮层神经细胞的保护作用
- Author:
Wencheng WAN
;
Haiyan LUO
;
Xiaoying LI
;
Jiefen LI
;
Shaoqiong ZHANG
- Publication Type:Journal Article
- Keywords:
Xingnaojing;
Ligustrazine;
neuron;
glutamic acid;
excitotoxicity
- From:
China Pharmacy
1991;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the protective effects of Xingnaojing(XNJ)and Ligustrazine(Lig)on rat's cortical neu_ rons of primary culture.METHODS:The effects of XNJ and Lig in counteracting the excitotoxicity of glutamic acid(10?l/L,3h)in rat's cortical neurons of primary culture were observed.RESULTS:Both XNJ and Lig could decrease the release of LDH from cells into culture medium and reduce the changes in cell morphology.CONCLUSION:XNJ or Lig can protect cultured cortical neurons from excitotoxicity of glutamic acid and more obvious effect can be initiated through combined use of them.
