VEGF Expression and its Clinical Significance in Human Liver Cancer Specimens
- VernacularTitle:肝癌组织血管内皮因子表达及其临床意义
- Author:
Daorong JIANG
;
Dengfu YAO
;
Young ZHU
- Publication Type:Journal Article
- Keywords:
VEGF;
Hepatocellular carcinoma;
ELISA;
Immunohistochemistry
- From:
Journal of Chinese Physician
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the roles of vascular endothelial growth factor (VEGF) in microvessel angiogennesis, development and metastasis of hepatocellular carcinoma (HCC). Methods The expression and cellular distributions of VEGF in HCCs were investigated by immunohistochemical method, and the levels of total RNA and VEGF also were quantitatively analysed in HCCs and paracancerous tissues. Results The positive rates of VEGF were 63 9% in all HCCs, 78 3% in non-encapsuled HCCs, and 90 9% in HCCs with extra-hepatic metastasis, respectively. VEGF expression was not associated with tumor size and differentiation degree. The total RNA level in HCCs was significantly lower than that in paracancerous and distal paracancerous tissues (P
