Expressions of E-cadherin, and ?-,?-catenin in Breast Cancers and Their Lymph-node Metastatic Tumors
- VernacularTitle:乳腺癌及淋巴结转移灶中上皮性钙粘素与?和?连接素的表达及意义
- Author:
Jianfeng YANG
;
Shaohua PENG
;
Senglin CHEN
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Cadherins;
Cytoskeletal proteins;
Metastasis
- From:
Journal of Chinese Physician
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protein expressions of E-cadherin and ?-,?-catenin in breast cancers and their lymph-node metastatic tumors to evaluate their possible role in breast cancer invasion and metastasis. Methods High sensitive S-P immunohistochemical method was used to detect the protein expressions of E-cadherin and ?-,?-catenin in 60 breast cancers(31cases with lymphatic metastasis) and their lymph-node metastatic tumors. Results The abnormal expression rates of the E-cadherin and ?-,?-catenin were 51 7%, 61 7%, 70% respectively in the 60 cases of breast cancers. The expression of E-cadherin was significantly associated with lymphatic metastasis(P
