Detection of Serum and Urinary TGF-?_1 in Patients with Primary Chronic Glomerulonephropathy and Its Clinical Significance
- VernacularTitle:原发性慢性肾小球疾病患者血清及尿TGF-?_1的检测及临床意义
- Author:
Hong GUO
;
Linying CAO
;
Jian DUAN
- Publication Type:Journal Article
- Keywords:
Glomerulonephropathy;
TGF-? 1
- From:
Journal of Chinese Physician
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore change and significance of serum and urinary transforming growth factor-? 1(TGF-? 1)in the patients with primary chronic glomerulonephropathy (PCG). Methods 65 patients with PCG were divided into four groups according to the degree of renal function damage: normal renal function,renal compensatory,renal decompensatory and renal function failure groups. Levels of serum and urinary TGF-? 1 were determined with ELISA, and the levels of urinary protein and renal function were examined as well. Results Levels of serum and urinary TGF-? 1 in patients with PCG were singificantly higher than those in control, and the levels of serum and urinary TGF-? 1 among four groups were significantly different. The TGF-? 1 level of urinary was associated with the degree of renal function damage(r=0 28,P
