Study on Deletion and Mutation of p16 Gene in Primary Pancreatic Carcinoma
- VernacularTitle:原发性胰腺癌中p16基因缺失和突变的研究
- Author:
Ruilian SHANG
;
Xiaoyan ZHAO
;
Qizhen QUAN
- Publication Type:Journal Article
- Keywords:
Primary pancreatic carcinoma;
p16 gene;
Deletion;
Mutation
- From:
Journal of Chinese Physician
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine deletion and mutation of p16 gene in primary pancreatic carcinoma to evaluate the relationsip between p16 gene alteration and carcinogenesis of pancreatic carcinoma as well as its progression. Methods Deletion and mutation of p16 gene in 28 primary pancreatic carcinomas and 28 normal tissues adjacent to tumors were detected by PCR-based deletion analysis technique and PCR-SSCP respectively, and the relationship between the results of detection and the clinical parameters was analysed. Results In 28 pancreatic carcinomas, homozygous deletion and mutation of p16 gene were found in 4 and 5 cases respectively. The frequency of p16 gene alteration was 32 1%. p16 gene alteration closely correlated with lymph node metastasis (P
