Expression of Th1/Th2 Cytokines in Patients with Cutaneous Nodular Vasculitis
- VernacularTitle:皮肤结节性血管炎患者Th1/Th2型细胞因子表达的研究
- Author:
Zaipei GUO
;
Hongjie LIU
;
Weiping LIU
;
Lin WANG
;
Fengyuan LI
;
Xiaoping DU
- Publication Type:Journal Article
- Keywords:
Vasculitis;
Nodular;
Cytokine
- From:
Chinese Journal of Dermatology
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between CD3+T, CD4+T, CD8+T cells, Th1/Th2 cytokines IL-2, IL-4, IL-6, sIL-2R and the pathogenesis as well as disease activity in patients with cutaneous nodular vasculitis (NV). Methods Cytokines IL-2, IL-6, sIL-2R and cell surface markers CD3+, CD4+ and CD8+ were detected by flow cytometry and ELISA with peripheral blood mononuclear cells from patients and controls. Expressions of IL-2, IL-4 and CD3+, CD4+, CD8+ were determined by immunohistochemistry in patients′ lesions in situ. Results Serum levels of IL-2, IL-6 and sIL-2R were significantly increased in patients with active NV compared with those in inactive stage(P
