Study on Extraction Technology of Berberine from Rhizoma Coptidis by the Method of Orthogonal-test Optimization
- VernacularTitle:正交试验优选黄连中小檗碱提取工艺的研究
- Author:
Sheng LIU
;
Liqin TANG
;
Liming CHEN
;
Chu LI
;
Shantang ZHANG
- Publication Type:Journal Article
- Keywords:
Rhizoma Coptidis;
berberine;
orthogonal-test;
extraction technology
- From:
China Pharmacy
1991;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To optimize the extraction technology of berberine from Rhizoma Coptidis.METHODS:The or?thogonal-test method was adopted to research the effects of5factors,including the concentration and volume of alcohol,the concentration of H 2 SO 4 ,the duration and times of extraction on the yielding rate of berberine from Rhizoma Coptidis.RESUL TS:The optimum technology of extracting berberine from Rhizoma Coptidis was described as follows:The concentration of al?cohol containing0.25%H 2 SO 4 was80%,and volume of alcohol was6times raw herb.To extract the herb for3times was optimum and duration of extraction was1.5h for each time.CONCLUSION:The content of berberine in the product is over90%,so this technology is suitable for industrialized production.
