The Pharmacokinetics Study of Amikacin in Old Patients with Respiratory System Infections
- VernacularTitle:阿米卡星在老年呼吸系统感染患者体内的药动学研究
- Author:
Haiyan CHEN
;
Wei HE
- Publication Type:Journal Article
- Keywords:
Amikacin;
old patients;
pharmacokinetics
- From:
China Pharmacy
1991;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:The pharmaceutics of Amikacin(AMK)in old patients with respiratory system infections was studied to provide a basis for clinical use.METHODS:Fluorescence polarizing immunoassay method was employed to detect blood drug concentration.RESULTS:The blood concentration-time curve of AMK fitted in with the two-compartment mod?el.The T 1/2? and AUC of AMK in the healthy volunteers and old patients with respiratory system infections were(2.14?0.81)h and(4.32?1.05)h(P
