Effect of apoptosis in the pathogenesis of the great saphenous varicose result ing from primary deep venous insufficiency
- VernacularTitle:细胞凋亡在原发性下肢深静脉功能不全的大隐静脉曲张发病中的作用
- Author:
Zuojun HU
;
Shenming WANG
;
Huixi WU
;
Hengwei YIN
;
Xuelin HUANG
- Publication Type:Journal Article
- Keywords:
VENOUS INSUFFIC IENCY/etiol;
VARICOSE VEINS/etiol;
APOPT OSIS
- From:
Chinese Journal of General Surgery
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the effect of apoptosis in the p athogenesis of great saphenous varicose(GSV) resulting from primary deep ven ous insufficiency (PDVI). Methods Apoptosis and Bcl-2 expres sion in the segment of first valve sinus of the GSV of PDVI of lower limbs w ere detected by transmission electron microscopy(TEM), agarose gel electrophore sis, TUNEL and immunohistochemistry. ResultsThere were 38 case s of PDVLs in experment group and 5 normal GSV in control group. In experiment group,the apoptosis cells(AC) (6.30? 2.70 )and apoptosis rate (AR)(0.42?2 .12) in the first valve sinus of GSV were significantly higher than those in control group(1.60?0.81,0.21?1.10,respectively)(all P
