Expression of STAR protein QKI in norepinephrine-induced rat cardiac hypertrophy
- VernacularTitle:STAR蛋白QKI在去甲肾上腺素诱导大鼠心肌肥厚时的表达变化
- Author:
Kai CHEN
;
Yao SONG
;
Jie YAN
;
Ping LI
;
Jinliang LI
;
Youyi ZHANG
- Publication Type:Journal Article
- Keywords:
Protein QKI;
Norepinephrine;
Cardiomegaly;
Ra ts
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the expression profile of QKI m RNA and protein in rat heart during pathological cardiac hypertrophy. ME THODS: A rat cardiac hypertrophy model was established using continuous norepinephrine (NE) perfusion. Real-time PCR and Western blotting were applied t o examine QKI mRNA and protein expression respectively in rat heart. RES ULTS: Both mRNA and protein of three QKI isoforms were detected in adult rat heart. QKI-5 mRNA and total QKI protein were remarkably decreased in NE-ind uced hypertrophic heart compared with those in control group (P
