Alterations of nitric oxide synthase in cardiac sarcoplasmic reticulum from rats with myocardial calcification
- VernacularTitle:心血管组织钙化大鼠心肌肌浆网一氧化氮合酶的改变
- Author:
Bin GENG
;
Shengying WU
;
Baohong ZHANG
;
Yongzheng PANG
;
Chaosh TANG
- Publication Type:Journal Article
- Keywords:
Calcification, pathologic;
Myocardium;
Sarcoplasm ic reticulum;
Nitric oxide;
Nitric-oxide synthase
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study alterations of nitric oxide synthase (NOS) in cardiac sarcop lasmic reticulum from rats with myocardial calcification, and to explore the mec hanism of inhibition of SR function in the rats with myocardial calcification. METHODS: The myocardial calcification rat models were prepared by vit amin D3 plus nicotine for 2 weeks and 6 weeks. Cardiac SR was separated by centrifugating. T he nitric oxide (NO) production, NOS activity and NOS protein expression in the SR were perfor med. RESULTS: Compared with control, myocardial calcium content in t he 6 weeks i ncreased by 408%(P
