Relationship between protein expression of MDM2 and P53 and hepatocar cinogenesis
- VernacularTitle:MDM2和P53蛋白表达与原发性肝细胞肝癌发生的关系
- Author:
Yunlong PAN
;
Li QIN
;
Guangyu JIANG
;
Lin YAN
;
Hua WANG
- Publication Type:Journal Article
- Keywords:
Carcinoma, hepatocellular;
Protein P53;
Pro tein MDM2
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the expression of MDM2 and muta nt-type P53 proteins in primary hepatocellular carcinoma(HCC). METHODS: Using immunohistochemical staining method(SP),the expression of mutant-t ype P53 and MDM2 proteins was examined in 55 cases of HCC,23 cases of correspond ing paracancerous tissues and 10 cases of normal hepatic tissues. RESULT S: The frequencies of MDM2 and P53 positive expression in HCC were 17/55 (30 9%) and 23/55 (41 8%), respectively. There was both positive expression of MDM2 and mutant-type P53 in 11 cases (20%) with HCC. Expression of MDM2 showed a significantly positive correlation with expression of mutant-type P53 (r=0 310,P
