Upregulation of neurokinin A levels by nerve growth factor in the experimental asthmatic guinea pig
- VernacularTitle:实验性哮喘时神经生长因子对神经激肽A的上调作用
- Author:
Xiubin FANG
;
Xiaoxiang LIU
;
Hong ZHANG
- Publication Type:Journal Article
- Keywords:
Nerve growth factor;
Neurokinin A;
Asthma;
Gu inea pig
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the regulatory mechanism of n erve growth factor (NGF) on neurokinin A in the experimental asthmatic guinea pi g. METHODS: Radioimmunoassay was used to determine the alteration of neurokinin A levels in the lower respiratory tract and visceral sensory afferent sites while NGF was absent (inhalation of NGF antibody through nasal cavity) in the asthmatic guinea pig. RESULTS: The contents of neurokinin A in the trachea, bronchus, lung, C 7-T 5 spinal ganglia and the correspondent spinal dorsal horn, nodose ganglia and solitary nucleus area in the experimental asthmatic guinea pig with the absent of NGF in the respiratory tract were much lower than those in the as thmatic and control groups (P
