Effects of amyloid ? on kinesin superfamily gene expression in hippo campus of rats
- VernacularTitle:淀粉样蛋白对大鼠海马神经元驱动蛋白超家族基因表达的影响
- Author:
Lei XU
;
Xin XU
;
Jinsong YAO
;
Lixia L
;
Xuel LI
- Publication Type:Journal Article
- Keywords:
Neurons;
Kinesin;
Amyloid;
Gene expression;
Hippocampus;
Rats
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of amyloid ? on the expres sion of kines in superfamily(KIF) genes in hippocampus of SD rats. METHODS: Th e model of Alzheimer's disease was established by injection of amyloid ? to bra in ventricle of rats. The learning impairment was verified by water maze test. The levels of mR NA for five kinesin superfamily genes, KIF1A, KIF2, KIF3A, KIF4, and KIF5A, in h ippocampus of rats, were estimated by RT-PCR. RESULTS: Two weeks after amyloid ? injection, the rats showed significant learning impairments. I n happocampus, the expression of KIF genes increased after amyloid ? injection. CONCLUSION: The increase in KIF gene expression may reflect th e excitotoxity of amyloid ? to neurons.
