Effect of Glucocorticoid on Disbalance of Th_1/Th_2 Cytokines in Asthmatic Patients
- VernacularTitle:糖皮质激素对哮喘患者Th_1/Th_2类细胞因子水平失衡的影响
- Author:
Xiaoyu ZHANG
;
Lihou ZHONG
- Publication Type:Journal Article
- Keywords:
Asthma;
Interleukin-12;
Interleukin-4;
Th 1/Th 2 cytokine;
Glucocorticoid
- From:
Journal of Chinese Physician
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of glucocorticoid on disbalance of the Th 1/Th 2 cytokines to investigate the mechanism of treatment of breathing in glucocorticoid in asthmatic patients. Methods The peripheral blood was drawn and the plasma IL-4,IL-12 and IgE of control group and patients were detected by ELISA method before and after glucocorticoid treatment. The results were analysed statistically. Results ⑴In asthmatic group, plasma IL-4 and IgE levels, and PEF variant rate after treatment were lower than those before treatment (P0.05); and ⑷ Correlation analysis showed that IL-4 level positively correlated with the IgE level and PEF variant rate(r=0.64,r=0.52;P
