Expression and Clinical Significance of Survivin in Acute Leukemia
- VernacularTitle:Survivin在急性白血病患者的表达及意义
- Author:
Zhongdong LI
;
Zhenhua QI
;
Guangping WANG
- Publication Type:Journal Article
- Keywords:
Gene, Survivin;
RT-PCR;
Leukemia, Acute
- From:
Journal of Chinese Physician
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression and clinical significance of survivin in acute leukemia. Methods By using semi-quantitative RT-PCR technique, survivin gene expression was detected in 43 acute leukemia(AL). Results Survivin gene expression rate in the cells of AL patients at diagnosis was 69.77%(30/43). Survivin mRNA expression rate in both 18 acute lymphocytic leukemia (ALL) and 25 acute nonlymphocytic leukemia(ANLL) (72.22% and 68.0% respectively) was signficantly higher than that in control group (33.33%,P0.05). Conclusions Survivin gene was highly expressed in AL patients and could be a potential target for treatment of AL.
