The Relationship Between Serum Cytokine and Liver Fibrosis in the Patients with Chronic Hepatitis B
- VernacularTitle:慢性乙肝患者血清细胞因子与肝纤维化的关系
- Author:
Yongnian SUN
;
Zhuqing HUANG
;
Bin XV
- Publication Type:Journal Article
- Keywords:
Chronic hepatitis B;
Cytokines;
Liver fibrosis;
Diagnosis
- From:
Journal of Chinese Physician
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between serum cytokines and liver fibrosis in patients with chronic hepatitis B(CHB), and to discuss their role in the pathogenesis of liver fibrosis. Methods ELISA and RIA techniques were used to detect the levels of transforming growth factor-?1( TGF-?1),tumor necrosis factor-?(TNF-?), Interferon -?(IFN-?), hyaline acid (HA), type III procollagen (PC Ⅲ) and collagen type Ⅳ(C-Ⅳ) in 95 patients with CHB, and contrast study were performed between those serum markers and hepatic pathology. Results The levels of serum TGF-?1, TNF-?, HA, PCⅢ and C-Ⅳ in the patients with CHB were significantly higher than those in normal control group (NC), and were correlated with degree of liver damage positively. Serum levels of TGF-?1, TNF-?, HA, PCⅢ and C-Ⅳ were positive proportion to degree of liver fibrosis (P
