The Expression and Significance of ICAM-1 on Myocardial Reperfusion Injury after Cardiac Transplantation in Rats
- VernacularTitle:ICAM-1在移植心脏缺血再灌注损伤中的表达及意义
- Author:
Mingkui ZHANG
;
Jianguo HU
;
Jinfu YANG
- Publication Type:Journal Article
- Keywords:
Cardiac transplantation;
Reperfusion injury;
Intercellular adhesion molecule-1;
Myeloperoxidase
- From:
Journal of Chinese Physician
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and significance of intercellular adhesion molecule-1 (ICAM-1) in graft reperfusion injury after cardiac transplantation in rats. Methods Twenty-four Wistar rats heterotopic cardiac transplantation models were randomly divided into control group (n=6) and experimental group (n=18). In control group, the ischemic period of the grafts was 60min without reperfusion. In experimental group, the grafts were respectively reperfused for 3h, 6h and 24h after 60min ischemic period. Immunohistochemical and biochemical techniques were used to detect myocardial ICAM-1 and myeloperoxidase (MPO). Results The expression of allograft ICAM-1 after reperfusion in experimental group was significantly higher than that in control group (P
