Relationship between retinal extracellular edema and vitreous contraction in rabbits
- VernacularTitle:兔视网膜细胞间水肿及玻璃体收缩性状改变的相关研究
- Author:
Jin MA
;
Dezheng WU
;
Rulong GAO
- Publication Type:Journal Article
- Keywords:
Macular edema, cystoid;
Retina;
Vitreous body
- From:
Chinese Journal of Ocular Fundus Diseases
1996;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between retinal extracellular edema and vitreous contraction in rabbits. Methods Seventeen pigmented rabbit models with retinal vein occlusion (RVO) was set up by laser photocoagulation. Retinal vascularity area was pathologically examined 1 month later. The vitreous gel length under the gravity condition and the percentage of its weight in the rabbits with extracellular edema was observed. The mechanisms were investigated by Western immunoblotting of type Ⅱ collagen. Results Extracellular edema was found in 13 experimental eyes 1 month after the formation of RVO (76.5%) with contracted vitreous gel and released watery liquid, and the ? component of type Ⅱcollagen was cross-linked together to form high-molecular-weight components of ? and ?, which weakened the stability of collagen net structure. Conclusions Vitreous contraction and retinal extracellular edema were correlated. The main reason may be the cross-links of vitreous collagen that damages the stability of collagen structure.
