Epileptic seizures after orthotopic liver transplantation:a report of 6 cases
- VernacularTitle:原位肝移植术后痫性发作六例病因分析
- Author:
Shuhong YI
;
Guihua CHEN
;
Xiaoshun HE
;
Xiaofeng ZHU
;
Minqiang LU
;
Yang YANG
;
Changjie CAI
;
Genshu WANG
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Epilepsy
- From:
Chinese Journal of General Surgery
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the etiology of epileptic seizures after orthotopic liver transplantation and preventive measures.MethodClinical data of 83 patients receiving orthotopic liver transplantation from May 1998 to December 2001 were retrospectively studied.ResultsSix cases suffered seizures with an incidence of 7.23%.The interval between transplantation and clinical diagnosis of seizures ranged from 4 to 15 days with a meadian time of 9.3?1.2 days. Tonic-clonic seizure was the most common type of seizures. Three patients had a previous history of seizure. Computed tomographic(CT) scan revealed strokes in 2 patients. Seizure related mortality was 3.61% in this group of 83 cases.ConclusionSeizures are not infrequent neurological complication after liver transplantation and it may indicate an underlying CNS lesions. Cyclosporine and tacrolimus neurotoxicity, metabolic abnormalities and pneumonia are factors contributing to the onset of seizures. Proper mangement and comprehensive therapy may improve the prognosis.
