Gene Mutation of RANTES and CCR5 in Systemic Lupus Erythematosus
- VernacularTitle:RANTES及其受体CCR5基因间的交互作用与系统性红斑狼疮相关性分析
- Author:
Dongqing YE
;
Shigui YANG
;
Xiangpei LI
;
Yisong HU
;
Jing YIN
;
Guoqing ZHANG
;
Jimin ZHU
;
Dongzhou CHEN
- Publication Type:Journal Article
- Keywords:
Polymorphism, single nucleotide;
Gene frequency;
RANTES;
Lupus erythematosus, systemic;
Recptors, CCR5
- From:
Chinese Journal of Dermatology
1995;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the gene mutation of RANTES and CCR5 in SLE and its significance. Methods One hundred and forty-six definitive SLE patients and 159 controls were collected. SNPs of RANTES promoter and polymorphism of CCR5 were performed by PCR or PCR/RFLP assay, and further confirmed by direct DNA sequencing. Results The frequence of RANTES-403G/G compounded with 28C/C and CCR5/CCR5 was significantly different between SLE and control groups (72.6% vs 58.5%, P 0.05). Conclusions These results indicate that the two SNPs are linkage disequilibrium. Interaction of two SNPs in RANTES and CCR5 is related with SLE. RANTES-403G/G compounded with 28C/C and CCR5/CCR5 may be one of risk factors of SLE. RANTES-403A is probably related with renal damage of SLE.
