Effect of Small and Large Ambroxol on Pulmonary Surfactant in Asthma Guinea-pig
- VernacularTitle:不同剂量氨溴索对哮喘豚鼠肺表面活性物质的影响
- Author:
Yanhui ZHENG
;
Shoujing KUAN
- Publication Type:Journal Article
- Keywords:
Ambroxol;
Asthma;
Pulmonary surfactants;
Animal model
- From:
Journal of Chinese Physician
2002;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe effect of small and large ambroxol on pulmonary surfactant in asthma guinea-pig. Methods 24 guinea-pigs were randomly divided into 4 groups;normal control group,asthma group, small dose ambroxol(7.5mg/kg.d)treated group, large dose ambroxol(30mg/kg.d)treated group. We detected total phospholipids(TPL),desaturated phosphatidylcholine(DSPC),total protein(TP) in broncho-alveolar lavage fluid(BALF).Results The levels of DSPC/TP? DSPC/TPL and DSPC of asthma group were statistically lower than normal control group P 0.05),were statistically higher than asthma group( P
