Expression of Ki-67,p53,bcl-2 and Bax in Gastric Globoid Dysplasia
- VernacularTitle:胃黏膜球样异型增生Ki-67、P53、bcl-2及bax的表达
- Author:
Xingong LI
;
Hongji DING
;
Aiying LI
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Globoid dysplasia;
Gastric mucosa;
Genes ,p53;
Genes ,Bcl-2;
Gene bax;
Immunohistochemistry
- From:
Journal of Chinese Physician
2002;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the expression of Ki-67,p53,bcl-2 and bax in gastric globoid dysplasia and the relationship between globoid dysplasia and gastric carcinoma.Methods An immunohistochemical staining was used to detect the expression of Ki-67,p53,bcl-2 and bax in 41 cases of gastric globoid dysplasia ,92 gastric carcinoma and 92 normal gastric mucosa.Results 41 cases gastic globoid dyplasia were seen in well differentiated adenocarcinoma,poor differentiated adnocarcinoma,mucinous adenocarcinoma and signet ring cell carcinoma.The histologic transition of globoid dysplasia to carcinoma was in 2 cases signet ring cell carcinoma and 3 poor differentiated tubular adenocarcinoma.Most cells of globoid dysplasia were positive of Ki-67,p53,bcl-2 and bax.The expression of Ki-67 and p53 in globoid dysplasia was higher than that in normal gastric mucosa and approached carcinoma level.The expression of bcl-2 was lower but of bax was higher in globoid dysplasia than that in normal.However,the expression of bcl-2 in higher grade globoid dysplasia was heightened.Conclusions Gastric globoid dysplasia is special active .It is possible that gastric globoid dysplasia is correlated to the occurrence of varied gastric carcinoma.
