Study on the Preparation of Azathioprine Liposomes
- VernacularTitle:硫唑嘌呤脂质体的研制
- Author:
Yalin DONG
;
Weihua DONG
- Publication Type:Journal Article
- Keywords:
azathioprine;
liposome;
entrapment ratio;
quality evaluation
- From:
China Pharmacy
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To optimize the formulation and preparation technic of azathioprine liposomes and evaluation the quality.METHODS:The liposomes were prepared by a film-vibration technique.The optimal formulation and preparation technic were selected by means of an orthogonal design test.The entrapment ratio of liposomes was studied by titrimetric method.The size distribution and appearance of liposomes were observed under microscope.RESULTS:The entrapment ratio of azathioprine liposomes was49.19%.The liposomes consisted of spherical or similar to spherical multilamellar vesicles with78.17%of particles in the liposomes smaller than2.4?m.CONCLUSION:The selected formulation and preparation technic of azathioprine liposomes are rational and stable.
