The expression of IFN-? and IL-4 on T lymphocytes that infiltrate in nasal polyps
- VernacularTitle:鼻息肉组织T淋巴细胞IFN-?、IL-4的表达
- Author:
Rong CHEN
;
Jianbo SHI
;
Geng XU
;
Jingfang DI
;
Shan ZENG
;
Yaoyin ZENG
- Publication Type:Journal Article
- Keywords:
Nasal polyps;
T-lymphocytes;
Interferon type Ⅱ;
Interleukin-4;
Flow cytometry
- From:
Chinese Journal of Pathophysiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the expression of Th1-typed cytokine IFN-? and Th2-typed cytokine IL-4 on T lymphocytes that infiltrate in nasal polyps for searching the pathogenesis of nasal polyps. METHODS: Nasal polyps tissue samples and peripheral blood were obtained from 21 patients. Normal human inferior turbinate mucosa and peripheral blood were obtained as well. Flow cytometry was adopted to detect the expression of IFN-? and IL-4 of T lymphocytes. RESULTS: Th cytokines were rarely detected in inferior turbinate from normal human. Nasal polyps tissue consisted of abundant T lymphocytes. The expression of IL-4 and IFN-? increased in peripheral blood from patients [(6 686?0 204)%, (64 312?1 611)%, respectively] compared with normal human [(0 560?0 051)%, (0 246?0 020)%, respectively] ( P
